The role of thyroglobulin in thyroid hormonogenesis.
Thyroglobulin (or “Tg” to be kinder to the tongue) is a substance made by thyroid cells. This is unique as no other tissue or cell in the body is capable of making Tg. Thyroid cells usually store Tg, but some of it leaks into the blood stream and can be measured in a blood sample. Patients with thyroid cancer who have been cured by surgery and radioiodine, have no detectable Tg in their.
Thyroglobulin, an approximately 670-kDa glycopeptide, is the major protein product of thyroid follicular cells; its rate of synthesis is increased by thyrotropin (TSH). After synthesis, it is modified by the attachment of iodine to selected tyrosine residues, which undergo rearrangement to form iodothyronines, particularly thyroxine (T4) and, to a lesser extent, thysonine (T3). Other.
Indeed, if any thyroid cancer cells are present, levels of thyroglobulin are often detectable, either on TSH suppression therapy or after stimulation with rhTSH (stimulated thyroglobulin testing). Measurement of thyroglobulin under these conditions has become standard practice in the follow up of patients with thyroid cancer. This study is an analysis of many other studies as to the usefulness.
Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible.
Thyroid hormones are hormones produced by the thyroid gland that have roles in metabolism. Thyroid hormones are two hormones produced and released by the thyroid gland, namely triiodothyronine (T 3) and thyroxine (T 4).They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth and neural maturation, and increase the body’s sensitivity to.
Hypothyroidism is a condition characterized by abnormally low amount of the thyroid hormone synthesis. This may be due to a thyroid problem or any other reason. Thyroid hormone affects growth, development, and many cellular processes. Inadequate thyroid hormone has many consequences for the body (1, 2, 3).
The thyroid gland is a butterfly-shaped organ and is composed of two cone-like lobes or wings, lobus dexter (right lobe) and lobus sinister (left lobe), connected via the isthmus. The organ is situated on the anterior side of the neck, lying against and around the larynx and trachea, reaching posteriorly the oesophagus and carotid sheath. It starts cranially at the oblique line on the thyroid.